IMPC phenotypes (gene matching)
B6.129-Gria2tm3Rsp/Kctt
| Status | Available to order |
| EMMA ID | EM:09212 |
| Citation information | RRID:IMSR_EM:09212 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Gria2tm3Rsp/Kctt |
| Alternative name | Gria2tm3Rsp (Lab name B-2) |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Gria2tm3Rsp |
| Gene/Transgene symbol | Gria2 |
Information from provider
| Provider | Rolf Sprengel |
| Provider affiliation | Molecular Neurobiology, Max-Planck-Institute for Medical Research |
| Genetic information | The GluA2fl floxed exon 11 allele allows deletion of the sequences encoding the glutamate receptor transmembrane domain ion channel pore in cells/tissues expressing Cre-recombinase. |
| Phenotypic information | Homozygous:No PhenotypeHeterozygous:No Phenotype |
| Breeding history | Backcrosses since 2004 |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
| Animals used for archiving | heterozygous males |
Disease and phenotype information
MGI phenotypes (gene matching)
- hippocampal neuron degeneration / MGI
- abnormal spinal cord morphology / MGI
- decreased body weight / MGI
- decreased body size / MGI
- hyperactivity / MGI
- jumpy / MGI
- hypoactivity / MGI
- impaired coordination / MGI
- decreased exploration in new environment / MGI
- abnormal grooming behavior / MGI
- decreased grooming behavior / MGI
- postnatal growth retardation / MGI
- absent long term depression / MGI
- impaired synaptic plasticity / MGI
- abnormal reflex / MGI
- abnormal touch/ nociception / MGI
- seizures / MGI
- abnormal motor capabilities/coordination/movement / MGI
- premature death / MGI
- abnormal nervous system electrophysiology / MGI
- abnormal emotion/affect behavior / MGI
- abnormal nociception after inflammation / MGI
- abnormal AMPA-mediated synaptic currents / MGI
- abnormal excitatory postsynaptic potential / MGI
- enhanced long term potentiation / MGI
- no phenotypic analysis / MGI
- abnormal response to novel object / MGI
- nervous system phenotype / MGI
- tonic-clonic seizures / MGI
- abnormal limb posture / MGI
- lethargy / MGI
- hearing/vestibular/ear phenotype / MGI
- hyperalgesia / MGI
- abnormal cell physiology / MGI
- increased susceptibility to neuronal excitotoxicity / MGI
- abnormal hippocampus CA3 region morphology / MGI
- decreased chemical nociceptive threshold / MGI
- paraparesis / MGI
- decreased grip strength / MGI
- enhanced AMPA-mediated synaptic currents / MGI
- postnatal lethality, complete penetrance / MGI
- postnatal lethality, incomplete penetrance / MGI
- abnormal circadian sleep/wake cycle / MGI
Literature references
- Forebrain-specific glutamate receptor B deletion impairs spatial memory but not hippocampal field long-term potentiation.;Shimshek Derya R, Jensen Vidar, Celikel Tansu, Geng Yu, Schupp Bettina, Bus Thorsten, Mack Volker, Marx Verena, Hvalby Øivind, Seeburg Peter H, Sprengel Rolf, ;2006;The Journal of neuroscience : the official journal of the Society for Neuroscience;26;8428-40; 16914668
- Impaired reproductive behavior by lack of GluR-B containing AMPA receptors but not of NMDA receptors in hypothalamic and septal neurons.;Shimshek Derya R, Bus Thorsten, Grinevich Valery, Single Frank N, Mack Volker, Sprengel Rolf, Spergel Daniel J, Seeburg Peter H, ;2006;Molecular endocrinology (Baltimore, Md.);20;219-31; 16099814
- The AMPA receptor subunit GluR-B in its Q/R site-unedited form is not essential for brain development and function.;Kask K, Zamanillo D, Rozov A, Burnashev N, Sprengel R, Seeburg P H, ;1998;Proceedings of the National Academy of Sciences of the United States of America;95;13777-82; 9811877
- Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival.;Kougioumtzidou Eleni, Shimizu Takahiro, Hamilton Nicola B, Tohyama Koujiro, Sprengel Rolf, Monyer Hannah, Attwell David, Richardson William D, ;2017;eLife;6;108824; 28608780
- Synaptic transmission and plasticity require AMPA receptor anchoring via its N-terminal domain.;Watson Jake F, Ho Hinze, Greger Ingo H, ;2017;eLife;6;; 28290985
- An inhalation anaesthesia approach for neonatal mice allowing streamlined stereotactic injection in the brain.;Ho Hinze, Fowle Adam, Coetzee Marisa, Greger Ingo H, Watson Jake F, ;2020;Journal of neuroscience methods;342;; 32569783