C3H.C-Mecom^Jbo/H

Status	Available to order
EMMA ID	EM:00091
International strain name	C3H.C-Mecom^Jbo/H
Alternative name	GENA251
Strain type	Induced Mutant Strains : Chemically-induced
Allele/Transgene symbol	Mecom^Jbo,
Gene/Transgene symbol	Mecom

Information from provider

Provider	Nick Parkinson
Provider affiliation	MRC Mammalian Genetics Unit
Phenotypic information	These mice have late onset deafness, an extra digit, reduced body weight and craniofacial defects
References	A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191 Mutation at the Evi1 locus in Junbo mice causes susceptibility to otitis media.;Parkinson Nicholas, Hardisty-Hughes Rachel E, Tateossian Hilda, Tsai Hsun-Tien, Brooker Debra, Morse Sue, Lalane Zuzanna, MacKenzie Francesca, Fray Martin, Glenister Pete, Woodward Anne-Marie, Polley Sian, Barbaric Ivana, Dear Neil, Hough Tertius A, Hunter A Jackie, Cheeseman Michael T, Brown Steve D M, ;2006;PLoS genetics;2;e149; 17029558

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI allele-associated human disease models

otitis media / DOID:10754

Orphanet associated rare diseases, based on orthologous gene matching

Radio-ulnar synostosis-amegakaryocytic thrombocytopenia syndrome / Orphanet_71289

IMPC phenotypes (allele matching)

decreased hematocrit / IMPC
decreased body weight / IMPC
abnormal startle reflex / IMPC
increased startle reflex / IMPC
limb grasping / IMPC
decreased hemoglobin content / IMPC
decreased erythrocyte cell number / IMPC
abnormal locomotor activation / IMPC
increased lean body mass / IMPC
decreased circulating iron level / IMPC
increased blood urea nitrogen level / IMPC
increased circulating amylase level / IMPC
decreased prepulse inhibition / IMPC
increased total body fat amount / IMPC

MGI phenotypes (allele matching)

abnormal craniofacial morphology / MGI
polydactyly / MGI
decreased body weight / MGI
increased susceptibility to otitis media / MGI
deafness / MGI
respiratory system inflammation / MGI
abnormal neutrophil differentiation / MGI
abnormal miscarriage rate / MGI
immune system phenotype / MGI
abnormal tympanic membrane morphology / MGI
tympanic membrane perforation / MGI
abnormal pinna reflex / MGI
hearing/vestibular/ear phenotype / MGI
impaired hearing / MGI
middle ear polyps / MGI
middle ear effusion / MGI
distended pericardium / MGI
abnormal forebrain morphology / MGI
brachydactyly / MGI
abnormal limb development / MGI
perinatal lethality, incomplete penetrance / MGI
embryonic lethality during organogenesis, incomplete penetrance / MGI
perinatal lethality, complete penetrance / MGI

Literature references

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191
Mutation at the Evi1 locus in Junbo mice causes susceptibility to otitis media.;Parkinson Nicholas, Hardisty-Hughes Rachel E, Tateossian Hilda, Tsai Hsun-Tien, Brooker Debra, Morse Sue, Lalane Zuzanna, MacKenzie Francesca, Fray Martin, Glenister Pete, Woodward Anne-Marie, Polley Sian, Barbaric Ivana, Dear Neil, Hough Tertius A, Hunter A Jackie, Cheeseman Michael T, Brown Steve D M, ;2006;PLoS genetics;2;e149; 17029558
Chronic otitis media is initiated by a bulla cavitation defect in the FBXO11 mouse model.;Del-Pozo Jorge, MacIntyre Neil, Azar Ali, Glover James, Milne Elspeth, Cheeseman Michael, ;2019;Disease models & mechanisms;12;3564-3577; 30898767
The EDA-deficient mouse has Zymbal's gland hypoplasia and acute otitis externa.;Del-Pozo Jorge, Headon Denis J, Glover James D, Azar Ali, Schuepbach-Mallepell Sonia, Bhutta Mahmood F, Riddell Jon, Maxwell Scott, Milne Elspeth, Schneider Pascal, Cheeseman Michael, ;2022;Disease models & mechanisms;15;985214; 35107126
Ectodysplasin signalling deficiency in mouse models of hypohidrotic ectodermal dysplasia leads to middle ear and nasal pathology.;Azar Ali, Piccinelli Chiara, Brown Helen, Headon Denis, Cheeseman Michael, ;2016;Human molecular genetics;25;95-112.e18; 27378689
Trans-cortical vessels in the mouse temporal bulla bone are a means to recruit myeloid cells in chronic otitis media and limit peripheral leukogram changes.;Azar Ali, Bhutta Mahmood F, Del-Pozo Jorge, Milne Elspeth, Cheeseman Michael, ;2022;Frontiers in genetics;13;69-79; 36246635
Limb development genes underlie variation in human fingerprint patterns.;Li Jinxi, Glover James D, Zhang Haiguo, Peng Meifang, Tan Jingze, Mallick Chandana Basu, Hou Dan, Yang Yajun, Wu Sijie, Liu Yu, Peng Qianqian, Zheng Shijie C, Crosse Edie I, Medvinsky Alexander, Anderson Richard A, Brown Helen, Yuan Ziyu, Zhou Shen, Xu Yanqing, Kemp John P, Ho Yvonne Y W, Loesch Danuta Z, Wang Lizhong, Li Yingxiang, Tang Senwei, Wu Xiaoli, Walters Robin G, Lin Kuang, Meng Ruogu, Lv Jun, Chernus Jonathan M, Neiswanger Katherine, Feingold Eleanor, Evans David M, Medland Sarah E, Martin Nicholas G, Weinberg Seth M, Marazita Mary L, Chen Gang, Chen Zhengming, Zhou Yong, Cheeseman Michael, Wang Lan, Jin Li, Headon Denis J, Wang Sijia, ;2022;Cell;185;29-46; 34995520
A new model for non-typeable Haemophilus influenzae middle ear infection in the Junbo mutant mouse.;Hood Derek, Moxon Richard, Purnell Tom, Richter Caroline, Williams Debbie, Azar Ali, Crompton Michael, Wells Sara, Fray Martin, Brown Steve D M, Cheeseman Michael T, ;2016;Disease models & mechanisms;9;; 26611891
Non-Typeable Haemophilus influenzae Infection of the Junbo Mouse.;Cheeseman Michael T, Hood Derek W, ;2017;Current protocols in mouse biology;7;; 28252201

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*

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C3H.C-MecomJbo/H