B6;129S6-Casp1tm1a(EUCOMM)Wtsi/Oulu

Status

Available to order

EMMA IDEM:08376
International strain nameB6;129S6-Casp1tm1a(EUCOMM)Wtsi/Oulu
Alternative nameCasp1 knock-out
Strain typeTargeted Mutant Strains
Allele/Transgene symbolCasp1tm1a(EUCOMM)Wtsi
Gene/Transgene symbolCasp1

Information from provider

ProviderMohamed Lamkanfi
Provider affiliationDept. of Medical Protein Research, VIB/Ghent University, Faculty of Medicine and Health Sciences
Genetic informationThe IKMC knock-out first targeting construct PG00146_Z_4_C11 was introduced into C57BL/6NCrl (male) x 129S6/SvEvTac (female) hybrid ES cells. Correct targeting was verified by PCR and Southern blotting. Chimeras were bred with C57BL/6OlaHsd mice and sperm was obtained from pups in the same background. In IVF, C57BL/6OlaHsd females were used as oocyte donors.
Phenotypic informationHomozygous:
Not analyzed

Heterozygous:
viable
References
  • Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation.;Van Gorp Hanne, Saavedra Pedro H V, de Vasconcelos Nathalia M, Van Opdenbosch Nina, Vande Walle Lieselotte, Matusiak Magdalena, Prencipe Giusi, Insalaco Antonella, Van Hauwermeiren Filip, Demon Dieter, Bogaert Delfien J, Dullaers Melissa, De Baere Elfride, Hochepied Tino, Dehoorne Joke, Vermaelen Karim Y, Haerynck Filomeen, De Benedetti Fabrizio, Lamkanfi Mohamed, ;2016;Proceedings of the National Academy of Sciences of the United States of America;113;14384-14389; 27911804
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreUniversity of Oulu, Oulu, Finland
Animals used for archivingheterozygous C57BL/6JOlaHsd, wild-type C57BL/6JOlaHsd
Stage of embryos2-cell

Literature references

  • Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation.;Van Gorp Hanne, Saavedra Pedro H V, de Vasconcelos Nathalia M, Van Opdenbosch Nina, Vande Walle Lieselotte, Matusiak Magdalena, Prencipe Giusi, Insalaco Antonella, Van Hauwermeiren Filip, Demon Dieter, Bogaert Delfien J, Dullaers Melissa, De Baere Elfride, Hochepied Tino, Dehoorne Joke, Vermaelen Karim Y, Haerynck Filomeen, De Benedetti Fabrizio, Lamkanfi Mohamed, ;2016;Proceedings of the National Academy of Sciences of the United States of America;113;14384-14389; 27911804

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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