STOCK Rag2tm1Fwa Cd40tm1Kik Tg(TcraH-Y,TcrbH-Y)71Vbo/Orl


Available to order

International strain nameSTOCK Rag2tm1Fwa Cd40tm1Kik Tg(TcraH-Y,TcrbH-Y)71Vbo/Orl
Alternative nameRag2-/- CD40-/- HY+/+Tg
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolRag2tm1Fwa,
Gene/Transgene symbolRag2

Information from provider

ProviderBenedita Rocha
Provider affiliationINSERM U 1020, INSERM
Additional ownerFrederick W. Alt, Hitoshi Kikutani, Harald von Boehmer
Genetic informationMutant mice bearing a transgenic alpha-beta TCR specific for the HY male antigen restricted to major histocompatibility complex (MHC) class II IAb, and deficient in the Cd40 gene and the Rag2 recombinase gene (TgRAG2) were used to obtain monoclonal populations of CD8+ T cells.
Phenotypic informationMice will have a single population of lymphocytes, those expressing the TCR transgene.
Breeding historyCurrently bred as homozygotes for the Rag2 and Cd40 knock-out mutations and the TCR transgene.
  • A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory.;Bourgeois Christine, Rocha Benedita, Tanchot Corinne, ;2002;Science (New York, N.Y.);297;2060-3; 12242444
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredyes

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Breeding at archiving centreMales are homozygous knock-out for Rag2 and Cd40, transgenic for the Tg(TcraH-Y,TcrbH-Y)71Vbo (HY) transgene. Females are homozygous knock-out for Rag2 and Cd40, heterozygous or wild-type for the Tg(TcraH-Y,TcrbH-Y)71Vbo (HY) transgene.
Stage of embryos2-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • decreased bone mineral density / MGI
  • abnormal dendritic cell physiology / MGI
  • increased susceptibility to bacterial infection / MGI
  • hematopoietic system phenotype / MGI
  • decreased cerebral infarction size / MGI
  • decreased platelet aggregation / MGI
  • decreased trabecular bone mass / MGI
  • decreased compact bone mass / MGI
  • decreased B cell number / MGI
  • immune system phenotype / MGI
  • absent germinal center B cells / MGI
  • decreased neutrophil cell number / MGI
  • abnormal humoral immune response / MGI
  • decreased IgA level / MGI
  • decreased immunoglobulin level / MGI
  • decreased IgE level / MGI
  • decreased susceptibility to type II hypersensitivity reaction / MGI
  • absent spleen germinal center / MGI
  • decreased IgG1 level / MGI
  • decreased IgG2a level / MGI
  • decreased IgG2b level / MGI
  • decreased IgG3 level / MGI
  • increased granulocyte number / MGI
  • abnormal spleen morphology / MGI
  • spleen hypoplasia / MGI
  • decreased body size / MGI
  • arrested B cell differentiation / MGI
  • decreased IgM level / MGI
  • thymus hypoplasia / MGI
  • arrested T cell differentiation / MGI
  • increased susceptibility to infection / MGI
  • abnormal effector T cell morphology / MGI
  • increased natural killer cell mediated cytotoxicity / MGI
  • decreased double-positive T cell number / MGI
  • increased macrophage cell number / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • lymph node hypoplasia / MGI
  • absent mature B cells / MGI
  • abnormal T cell receptor V(D)J recombination / MGI
  • abnormal immunoglobulin V(D)J recombination / MGI
  • decreased thymocyte number / MGI
  • lung inflammation / MGI
  • abnormal macrophage physiology / MGI
  • colitis / MGI
  • abnormal T-helper 1 physiology / MGI
  • abnormal response to transplant / MGI
  • abnormal interferon secretion / MGI
  • abnormal chemokine secretion / MGI
  • decreased susceptibility to bacterial infection induced morbidity/mortality / MGI
  • abnormal intestinal mucosa morphology / MGI
  • abnormal B cell morphology / MGI
  • decreased susceptibility to parasitic infection / MGI
  • decreased double-negative T cell number / MGI
  • increased double-negative T cell number / MGI
  • decreased susceptibility to type IV hypersensitivity reaction / MGI
  • abnormal stomach mucosa morphology / MGI
  • abnormal intestinal epithelium morphology / MGI
  • abnormal B cell number / MGI
  • decreased pre-B cell number / MGI
  • decreased mature B cell number / MGI
  • increased immature B cell number / MGI
  • decreased immature B cell number / MGI
  • abnormal gamma-delta T cell differentiation / MGI

Literature references

  • A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory.;Bourgeois Christine, Rocha Benedita, Tanchot Corinne, ;2002;Science (New York, N.Y.);297;2060-3; 12242444

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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