Available to order

International strain nameNOD.129S2-Parp1tm1Zqw/Ieg
Alternative nameNOD-Parp1tm1Zqw
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolParp1tm1Zqw,
Gene/Transgene symbolParp1

Information from provider

ProviderVolker Burkart
Provider affiliationInstitute for Clinical Diabetology, German Diabetes Center
Additional ownerDr. Z.Q. Wang, Leibniz Institute for Age Research - Fritz Lipmann Institute, Jena, Germany
Genetic informationA promoterless neomycin gene replaced part of exon 2 and intron 2. The neomycin sequences were fused in-frame to the coding sequence of the gene. Northern blot analysis detected a truncated fusion transcript in homozygous mice. Enzyme activity assays demonstrated a lack of functional ADPRT1 protein in homozygous mice.
Phenotypic informationAbnormal sensitivity of pancreatic islet cells to beta cell damaging mediators.
Breeding historyMore than 10 backcross generations to female NOD. Every 2nd generation intercrossed, currently inbred.
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

MGI phenotypes (allele matching)
  • decreased inflammatory response / MGI
  • decreased neuron apoptosis / MGI
  • abnormal response/metabolism to endogenous compounds / MGI
  • abnormal microglial cell physiology / MGI
  • decreased susceptibility to kidney reperfusion injury / MGI
  • increased renal glomerular filtration rate / MGI
  • decreased circulating creatinine level / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • decreased renal tubule apoptosis / MGI
  • immune system phenotype / MGI
  • enhanced wound healing / MGI
  • decreased susceptibility to injury / MGI
  • decreased cell proliferation / MGI
  • skin hyperplasia / MGI
  • decreased susceptibility to dopaminergic neuron neurotoxicity / MGI

Information on how we integrate external resources can be found here



Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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