IMPC phenotypes (gene matching)
- decreased exploration in new environment / IMPC
C57BL/6N-Cited4tm1.1Arte/Ieg
| Status | Available to order |
| EMMA ID | EM:05491 |
| Citation information | RRID:IMSR_EM:05491 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Cited4tm1.1Arte/Ieg |
| Alternative name | Cited 4 KO cond |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Cited4tm1.1Arte |
| Gene/Transgene symbol | Cited4 |
Information from provider
| Provider | Helmholtz Zentrum Muenchen |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen German Research Center for Environmental Health (GmbH) |
| Genetic information | The complete mouse Cited4 ORF is encoded by exon 1. Exon 1 including 1.5 kb of the promoter region has been flanked by loxP sites, as its genetic ablation should result in loss of function. The conditional targeted mutation has been obtained by in vivo, Flp recombinase-mediated removal of the neomycin selection marker. |
| Phenotypic information | TO BE PROVIDED |
| Breeding history | Targeting performed in C57BL/6N ES cells and confirmed by Southern blotting. Crossed to C57BL/6N-Tg(CAG-flpe)2Arte mice to obtain mutant founders with excised neo cassette. Maintained on C57BL/6N background. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6NTac males, wild-type C57BL/6N females |
| Stage of embryos | 2-cell |
Disease and phenotype information
MGI phenotypes (gene matching)
- no phenotypic analysis / MGI
Literature references
- Cited4 is a sex-biased mediator of the antidiabetic glitazone response in adipocyte progenitors.;Bayindir-Buchhalter Irem, Wolff Gretchen, Lerch Sarah, Sijmonsma Tjeerd, Schuster Maximilian, Gronych Jan, Billeter Adrian T, Babaei Rohollah, Krunic Damir, Ketscher Lars, Spielmann Nadine, Hrabe de Angelis Martin, Ruas Jorge L, Müller-Stich Beat P, Heikenwalder Mathias, Lichter Peter, Herzig Stephan, Vegiopoulos Alexandros, ;2018;EMBO molecular medicine;10;631-646; 29973382
- CITED4 Protects Against Adverse Remodeling in Response to Physiological and Pathological Stress.;Lerchenmüller Carolin, Rabolli Charles P, Yeri Ashish, Kitchen Robert, Salvador Ane M, Liu Laura X, Ziegler Olivia, Danielson Kirsty, Platt Colin, Shah Ravi, Damilano Federico, Kundu Piyusha, Riechert Eva, Katus Hugo A, Saffitz Jeffrey E, Keshishian Hasmik, Carr Steven A, Bezzerides Vassilios J, Das Saumya, Rosenzweig Anthony, ;2020;Circulation research;127;; 32418505