Available to order

International strain nameB6.129-Cd81tm1Lvy/Orl
Alternative nameB6-backcrossed Cd81 knockout
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolCd81tm1Lvy,
Gene/Transgene symbolCd81

Information from provider

ProviderShoshana Levy
Provider affiliationDepartment of Bioengineering, Stanford University
Genetic informationCd81 knockout mice.
Phenotypic informationFemale infertility, resistance to infection by Plasmodium sporozoites, impairment in the immune and nervous systems.
Breeding historyFemale infertility of Cd81 mice was manifested after the 4th backcross to a homozygous background (C57BL/6 and BALB/c). The mice have been backcrossed onto the C57BL/6 background for at least 8 generation.
  • Normal lymphocyte development but delayed humoral immune response in CD81-null mice.;Maecker H T, Levy S, ;1997;The Journal of experimental medicine;185;1505-10; 9126932
Homozygous fertileno
Homozygous viableyes
Homozygous matings requiredno

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivinghomozygous C57BL/6J, wild-type C57BL/6J
Stage of embryos2-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • thickened cerebral cortex / MGI
  • increased brain weight / MGI
  • abnormal T-helper 2 physiology / MGI
  • decreased susceptibility to type I hypersensitivity reaction / MGI
  • increased hippocampus volume / MGI
  • nervous system phenotype / MGI
  • decreased IgG level / MGI
  • abnormal B cell morphology / MGI
  • decreased susceptibility to parasitic infection / MGI
  • decreased IgG1 level / MGI
  • abnormal hippocampus morphology / MGI
  • abnormal CNS glial cell morphology / MGI
  • abnormal neuron morphology / MGI
  • abnormal hippocampus CA1 region morphology / MGI
  • abnormal hippocampus pyramidal cell morphology / MGI
  • increased astrocyte number / MGI
  • abnormal microglial cell morphology / MGI
  • abnormal corpus callosum morphology / MGI

Literature references

  • Normal lymphocyte development but delayed humoral immune response in CD81-null mice.;Maecker H T, Levy S, ;1997;The Journal of experimental medicine;185;1505-10; 9126932

Information on how we integrate external resources can be found here



Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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