STOCK Gt(ROSA)26Sortm2(cre/ERT2)Brn/Cnrm
Status | Available to order |
EMMA ID | EM:00410 |
International strain name | STOCK Gt(ROSA)26Sortm2(cre/ERT2)Brn/Cnrm |
Alternative name | RCM2 |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Gt(ROSA)26Sortm2(cre/ERT2)Brn, |
Gene/Transgene symbol | Gt(ROSA)26Sor |
Information from provider
Provider | Anton Berns |
Provider affiliation | Research - Animal Facility, The Netherlands Cancer Institute |
Genetic information | Knock-in of cre recombinase/ERT2, pgk-puromycin resistance cassette in the Gt(ROSA)26Sor gene. Similar to Vooijs et al. EMBO Rep, 2001 (4) 292-297. |
Phenotypic information | RCM2 mice show no obvious phenotype. |
Breeding history | Mutation was introduced in a 129 ES line, backcrossed to C57BL/6 background. The RCM2 strain is now being backcrossed to FVB/N. |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Toxicity of ligand-dependent Cre recombinases and generation of a conditional Cre deleter mouse allowing mosaic recombination in peripheral tissues.;Hameyer Dorothe, Loonstra Ate, Eshkind Leonid, Schmitt Steffen, Antunes Cecilia, Groen Annemiek, Bindels Eric, Jonkers Jos, Krimpenfort Paul, Meuwissen Ralph, Rijswijk Loes, Bex Axel, Berns Anton, Bockamp Ernesto, ;2007;Physiological genomics;31;32-41; 17456738
- Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice.;Loftus Róisín M, Assmann Nadine, Kedia-Mehta Nidhi, O'Brien Katie L, Garcia Arianne, Gillespie Conor, Hukelmann Jens L, Oefner Peter J, Lamond Angus I, Gardiner Clair M, Dettmer Katja, Cantrell Doreen A, Sinclair Linda V, Finlay David K, ;2018;Nature communications;9;2341; 29904050
- Natural Killer Cells Integrate Signals Received from Tumour Interactions and IL2 to Induce Robust and Prolonged Anti-Tumour and Metabolic Responses.;Kedia-Mehta Nidhi, Choi Chloe, McCrudden Aisling, Littwitz-Salomon Elisabeth, Fox Proinnsias G, Gardiner Clair M, Finlay David K, ;2019;Immunometabolism;1;e190014; 31595191
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