C3;C-FlnaDilp2/H

Status

Available to order

EMMA IDEM:00387
International strain nameC3;C-FlnaDilp2/H
Alternative nameGENA379, Dilp2 (Dilated pupils 2)
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolFlnaDilp2,
Gene/Transgene symbolFlna

Information from provider

ProviderCaroline Thaung
Provider affiliationMRC Mammalian Genetics Unit
Phenotypic informationMice heterozygous for this mutation have dilated pulpils. Homozygous animals are not generated.
References
  • Cardiac malformations and midline skeletal defects in mice lacking filamin A.;Hart Alan W, Morgan Joanne E, Schneider Jürgen, West Katrine, McKie Lisa, Bhattacharya Shoumo, Jackson Ian J, Cross Sally H, ;2006;Human molecular genetics;15;2457-67; 16825286
  • A meckelin-filamin A interaction mediates ciliogenesis.;Adams Matthew, Simms Roslyn J, Abdelhamed Zakia, Dawe Helen R, Szymanska Katarzyna, Logan Clare V, Wheway Gabrielle, Pitt Eva, Gull Keith, Knowles Margaret A, Blair Edward, Cross Sally H, Sayer John A, Johnson Colin A, ;2012;Human molecular genetics;21;1272-86; 22121117

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal eye morphology / MGI
  • mydriasis / MGI
  • abnormal sternum morphology / MGI
  • abnormal xiphoid process morphology / MGI
  • double outlet right ventricle / MGI
  • irregularly shaped pupil / MGI
  • abnormal palatal shelf fusion at midline / MGI
  • ventricular septal defect / MGI
  • prenatal lethality, complete penetrance / MGI

Literature references

  • Cardiac malformations and midline skeletal defects in mice lacking filamin A.;Hart Alan W, Morgan Joanne E, Schneider Jürgen, West Katrine, McKie Lisa, Bhattacharya Shoumo, Jackson Ian J, Cross Sally H, ;2006;Human molecular genetics;15;2457-67; 16825286
  • A meckelin-filamin A interaction mediates ciliogenesis.;Adams Matthew, Simms Roslyn J, Abdelhamed Zakia, Dawe Helen R, Szymanska Katarzyna, Logan Clare V, Wheway Gabrielle, Pitt Eva, Gull Keith, Knowles Margaret A, Blair Edward, Cross Sally H, Sayer John A, Johnson Colin A, ;2012;Human molecular genetics;21;1272-86; 22121117
  • Filamin a regulates neural progenitor proliferation and cortical size through Wee1-dependent Cdk1 phosphorylation.;Lian Gewei, Lu Jie, Hu Jianjun, Zhang Jingping, Cross Sally H, Ferland Russell J, Sheen Volney L, ;2012;The Journal of neuroscience : the official journal of the Society for Neuroscience;32;7672-84; 22649246

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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