B6.C-Cited2m1H/H
| Status | Available to order |
| EMMA ID | EM:03112 |
| International strain name | B6.C-Cited2m1H/H |
| Alternative name | Cited2-L247P |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Cited2m1H, |
| Gene/Transgene symbol | Cited2 |
Information from provider
| Provider | Shoumo Bhattacharya |
| Provider affiliation | Dept of Cardiovascular Medicine, University of Oxford |
| Additional owner | The original mutation was identified from the MRC-Harwell's paired DNA-sperm library of ENU-mutagenised males. Harwell Science and Innovation Campus Oxfordshire OX11 0RD UK |
| Genetic information | The original mutation was identified from the MRC-Harwell's paired DNA-sperm library of ENU-mutagenised males. The molecular lesion is a L to P change at residue 247 in Cited2. |
| Phenotypic information | Although the amino acid change occurs in a highly conserved residue, the mutant is homozygous viable and fertile, with no detectable phenotype. In trans to the knock-out allele, it is viable and phenotypically normal. |
| Breeding history | The line is maintained by backcrossing to C57BL/6J. It has been backcrossed 9 generations. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous C57BL/6J |
| Breeding at archiving centre | Males were archived upon arrival. No breeding was carried out at the archiving centre. |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Atrial septal defect, sinus venosus type / Orphanet_99105
- Atrial septal defect, ostium secundum type / Orphanet_99103