B6.C-Cited2m1H/H

Status

Available to order

EMMA IDEM:03112
Citation informationRRID:IMSR_EM:03112 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6.C-Cited2m1H/H
Alternative nameCited2-L247P
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolCited2m1H
Gene/Transgene symbolCited2

Information from provider

ProviderShoumo Bhattacharya
Provider affiliationDept of Cardiovascular Medicine, University of Oxford
Additional ownerThe original mutation was identified from the MRC-Harwell's paired DNA-sperm library of ENU-mutagenised males. Harwell Science and Innovation Campus Oxfordshire OX11 0RD UK
Genetic informationThe original mutation was identified from the MRC-Harwell's paired DNA-sperm library of ENU-mutagenised males. The molecular lesion is a L to P change at residue 247 in Cited2.
Phenotypic informationAlthough the amino acid change occurs in a highly conserved residue, the mutant is homozygous viable and fertile, with no detectable phenotype. In trans to the knock-out allele, it is viable and phenotypically normal.
Breeding historyThe line is maintained by backcrossing to C57BL/6J. It has been backcrossed 9 generations.
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous C57BL/6J males
Breeding at archiving centreMales were archived upon arrival. No breeding was carried out at the archiving centre.

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • abnormal neurocranium morphology / MGI
  • abnormal blood flow velocity / MGI
  • abnormal heart morphology / MGI
  • abnormal heart development / MGI
  • overriding aortic valve / MGI
  • abnormal interventricular septum morphology / MGI
  • double outlet right ventricle / MGI
  • abnormal atrioventricular cushion morphology / MGI
  • decreased atrioventricular cushion size / MGI
  • abnormal pulmonary trunk morphology / MGI
  • right-sided isomerism / MGI
  • abnormal kidney development / MGI
  • right pulmonary isomerism / MGI
  • dextrocardia / MGI
  • mesocardia / MGI
  • small spleen / MGI
  • exencephaly / MGI
  • open neural tube / MGI
  • fused dorsal root ganglion / MGI
  • small dorsal root ganglion / MGI
  • abnormal cranial ganglia morphology / MGI
  • abnormal lung development / MGI
  • decreased embryo size / MGI
  • abnormal embryo turning / MGI
  • abnormal left-right axis patterning / MGI
  • edema / MGI
  • postnatal lethality / MGI
  • abnormal neural tube morphology / MGI
  • no abnormal phenotype detected / MGI
  • hydrops fetalis / MGI
  • abnormal pulmonary alveolus morphology / MGI
  • abnormal pulmonary alveolus epithelial cell morphology / MGI
  • abnormal type I pneumocyte morphology / MGI
  • abnormal type II pneumocyte morphology / MGI
  • persistent truncus arteriosis / MGI
  • situs inversus / MGI
  • abnormal heart atrium morphology / MGI
  • abnormal aortic arch morphology / MGI
  • interrupted aortic arch / MGI
  • right aortic arch / MGI
  • decreased fetal size / MGI
  • abnormal direction of heart looping / MGI
  • abnormal surfactant secretion / MGI
  • abnormal neural fold formation / MGI
  • abnormal heart ventricle morphology / MGI
  • absent adrenal gland / MGI
  • homeostasis/metabolism phenotype / MGI
  • impaired lung alveolus development / MGI
  • atrioventricular valve regurgitation / MGI
  • right atrial isomerism / MGI
  • abnormal inferior vena cava morphology / MGI
  • abnormal heart position or orientation / MGI
  • abnormal cardiac outflow tract development / MGI
  • abnormal spinal cord central canal morphology / MGI
  • abnormal basicranium morphology / MGI
  • ventricular septal defect / MGI
  • atrial septal defect / MGI
  • ostium primum atrial septal defect / MGI
  • common atrium / MGI
  • abnormal heart and great artery attachment / MGI
  • abnormal truncus arteriosus septation / MGI
  • pulmonary artery stenosis / MGI
  • aberrant origin of the right subclavian artery / MGI
  • vascular ring / MGI
  • common atrioventricular valve / MGI
  • iris coloboma / MGI
  • abnormal stomach position or orientation / MGI
  • absent alveolar lamellar bodies / MGI
  • small lung lobe / MGI
  • perinatal lethality, complete penetrance / MGI
  • lethality throughout fetal growth and development, complete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • embryonic lethality during organogenesis, incomplete penetrance / MGI
  • increased embryonic neuroepithelium apoptosis / MGI
  • abnormal cardiac neural crest cell morphology / MGI
  • decreased cardiac neural crest cell number / MGI
  • absent cardiac neural crest cells / MGI
  • abnormal tail position or orientation / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

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