IMPC phenotypes (gene matching)
B6.129X1-Thtm1(cre)Te/Kieg
| Status | Available to order |
| EMMA ID | EM:00254 |
| International strain name | B6.129X1-Thtm1(cre)Te/Kieg |
| Alternative name | Th-IRES-Cre |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Thtm1(cre)Te |
| Gene/Transgene symbol | Th |
Information from provider
| Provider | Ted Ebendal |
| Provider affiliation | Department of Neuroscience, Uppsala University |
| Genetic information | The cre recombinase (derived from te pMC-Cre plamid obtained by Klaus Rajewsky) was cloned following an IRES sequence (obtained from Austin Smith). An frt-flanked neomycin selection cassette was added and the construct cloned in the 3' untranslated end of the tyrosine hydroxylase (Th) gene (as described by Althini et al., 2003, J Neurosci Res 72: 444-453). The coding sequence of Th is not affected, nor are the expression levels, so both the TH and cre recombinase proteins are produced in Th-expressing cells of this mouse line. |
| Phenotypic information | No phenotypic manifestations noted. |
| Breeding history | Generated by blastocyst injection of 129/SvJ ES cells into C57BL/6J blastocysts. The frt-flanked neo cassette has been eliminated by crossing with FLP-deleter mice (Susan Dymecki). Maintained since year 2000 by backcrossing to our colony of C57BL/6J originating from Bomholtgard (Denmark). Currently we maintain neo-minus N11 mice. |
| References |
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Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
| Animals used for archiving | heterozygous , wild-type C57BL/6J |
| Stage of embryos | 2-cell |
Disease and phenotype information
MGI phenotypes (gene matching)
- vasculature congestion / MGI
- abnormal heart development / MGI
- ventricular hypoplasia / MGI
- weakness / MGI
- atelectasis / MGI
- decreased body weight / MGI
- decreased body size / MGI
- abnormal cued conditioning behavior / MGI
- abnormal motor coordination/balance / MGI
- respiratory failure / MGI
- abnormal associative learning / MGI
- abnormal learning/memory/conditioning / MGI
- no abnormal phenotype detected / MGI
- anoxia / MGI
- abnormal active avoidance behavior / MGI
- abnormal conditioned taste aversion behavior / MGI
- no phenotypic analysis / MGI
- abnormal heart atrium morphology / MGI
- dilated heart atrium / MGI
- abnormal ST segment / MGI
- abnormal adrenaline level / MGI
- abnormal noradrenaline level / MGI
- bradykinesia / MGI
- decreased heart rate / MGI
- decreased dopamine level / MGI
- abnormal fetal cardiomyocyte morphology / MGI
- visceral vascular congestion / MGI
- liver vascular congestion / MGI
- heart vascular congestion / MGI
- increased serotonin level / MGI
- postnatal lethality, complete penetrance / MGI
- neonatal lethality, complete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- lethality throughout fetal growth and development, incomplete penetrance / MGI
- decreased noradrenaline level / MGI
Literature references
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- Optogenetic interrogation of dopaminergic modulation of the multiple phases of reward-seeking behavior.;Adamantidis Antoine R, Tsai Hsing-Chen, Boutrel Benjamin, Zhang Feng, Stuber Garret D, Budygin Evgeny A, Touriño Clara, Bonci Antonello, Deisseroth Karl, de Lecea Luis, ;2011;The Journal of neuroscience : the official journal of the Society for Neuroscience;31;10829-35; 21795535
- Dopamine triggers heterosynaptic plasticity.;Ishikawa Masago, Otaka Mami, Huang Yanhua H, Neumann Peter A, Winters Bradley D, Grace Anthony A, Schlüter Oliver M, Dong Yan, ;2013;The Journal of neuroscience : the official journal of the Society for Neuroscience;33;6759-65; 23595734
- A locus coeruleus to dentate gyrus noradrenergic circuit modulates aversive contextual processing.;Seo Dong-Oh, Zhang Eric T, Piantadosi Sean C, Marcus David J, Motard Laura E, Kan Bryce K, Gomez Adrian M, Nguyen Tammy K, Xia Li, Bruchas Michael R, ;2021;Neuron;109;2116-2130.e6; 34081911
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- Engineered AAVs for non-invasive gene delivery to rodent and non-human primate nervous systems.;Chen Xinhong, Ravindra Kumar Sripriya, Adams Cameron D, Yang Daping, Wang Tongtong, Wolfe Damien A, Arokiaraj Cynthia M, Ngo Victoria, Campos Lillian J, Griffiths Jessica A, Ichiki Takako, Mazmanian Sarkis K, Osborne Peregrine B, Keast Janet R, Miller Cory T, Fox Andrew S, Chiu Isaac M, Gradinaru Viviana, ;2022;Neuron;110;2242-2257.e6; 35643078
- Cardiovascular baroreflex circuit moonlights in sleep control.;Yao Yuanyuan, Barger Zeke, Saffari Doost Mohammad, Tso Chak Foon, Darmohray Dana, Silverman Daniel, Liu Danqian, Ma Chenyan, Cetin Ali, Yao Shenqin, Zeng Hongkui, Dan Yang, ;2022;Neuron;110;3986-3999.e6; 36170850
- Control of Non-REM Sleep by Midbrain Neurotensinergic Neurons.;Zhong Peng, Zhang Zhe, Barger Zeke, Ma Chenyan, Liu Danqian, Ding Xinlu, Dan Yang, ;2019;Neuron;104;795-809.e6; 31582313
- Sleep Regulation by Neurotensinergic Neurons in a Thalamo-Amygdala Circuit.;Ma Chenyan, Zhong Peng, Liu Danqian, Barger Zeke Katsh, Zhou Li, Chang Wei-Cheng, Kim Brian, Dan Yang, ;2019;Neuron;103;323-334.e7; 31178114
- Dorsal Raphe Dopamine Neurons Modulate Arousal and Promote Wakefulness by Salient Stimuli.;Cho Jounhong Ryan, Treweek Jennifer B, Robinson J Elliott, Xiao Cheng, Bremner Lindsay R, Greenbaum Alon, Gradinaru Viviana, ;2017;Neuron;94;1205-1219.e8; 28602690
- Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior.;Hunn Benjamin H M, Vingill Siv, Threlfell Sarah, Alegre-Abarrategui Javier, Magdelyns Morgane, Deltheil Thierry, Bengoa-Vergniory Nora, Oliver Peter L, Cioroch Milena, Doig Natalie M, Bannerman David M, Cragg Stephanie J, Wade-Martins Richard, ;2019;Cell reports;29;920-931.e7; 31644913
- Phasic dopamine release in the medial prefrontal cortex enhances stimulus discrimination.;Popescu Andrei T, Zhou Michael R, Poo Mu-Ming, ;2016;Proceedings of the National Academy of Sciences of the United States of America;113;E3169-76; 27185946
- Sympathetic innervation of the mouse kidney and liver arising from prevertebral ganglia.;Torres Hayden, Huesing Clara, Burk David H, Molinas Adrien J R, Neuhuber Winfried L, Berthoud Hans-Rudolf, Münzberg Heike, Derbenev Andrei V, Zsombok Andrea, ;2021;American journal of physiology. Regulatory, integrative and comparative physiology;321;R328-R337; 34231420
- Mechanism for Hypocretin-mediated sleep-to-wake transitions.;Carter Matthew E, Brill Julia, Bonnavion Patricia, Huguenard John R, Huerta Ramon, de Lecea Luis, ;2012;Proceedings of the National Academy of Sciences of the United States of America;109;E2635-44; 22955882
- VTA dopaminergic neurons regulate ethologically relevant sleep-wake behaviors.;Eban-Rothschild Ada, Rothschild Gideon, Giardino William J, Jones Jeff R, de Lecea Luis, ;2016;Nature neuroscience;19;1356-66; 27595385
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- Sympathetic innervation of inguinal white adipose tissue in the mouse.;Huesing Clara, Qualls-Creekmore Emily, Lee Nathan, François Marie, Torres Hayden, Zhang Rui, Burk David H, Yu Sangho, Morrison Christopher D, Berthoud Hans-Rudolf, Neuhuber Winfried, Münzberg Heike, ;2021;The Journal of comparative neurology;529;3-13; 32935348
- Sympathetic innervation of the interscapular brown adipose tissue in mouse.;François Marie, Torres Hayden, Huesing Clara, Zhang Rui, Saurage Carson, Lee Nathan, Qualls-Creekmore Emily, Yu Sangho, Morrison Christopher D, Burk David, Berthoud Hans Rudolf, Münzberg Heike, ;2019;Annals of the New York Academy of Sciences;1454;6455-60; 31184376
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- Optogenetic Activation of A11 Region Increases Motor Activity.;Koblinger Kathrin, Jean-Xavier Céline, Sharma Sandeep, Füzesi Tamás, Young Leanne, Eaton Shane E A, Kwok Charlie Hong Ting, Bains Jaideep Singh, Whelan Patrick J, ;2018;Frontiers in neural circuits;12;18451; 30364230
- Ventral Tegmental Area Projection Regulates Glutamatergic Transmission in Nucleus Accumbens.;Yu Jun, Ishikawa Masago, Wang Junshi, Schlüter Oliver M, Sesack Susan R, Dong Yan, ;2019;Scientific reports;9;e66122; 31804595
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- Neurons in the caudal ventrolateral medulla mediate descending pain control.;Gu Xinglong, Zhang Yizhen Z, O'Malley John J, De Preter Caitlynn C, Penzo Mario, Hoon Mark A, ;2023;Nature neuroscience;26;7972; 36894654
- Parallel descending dopaminergic connectivity of A13 cells to the brainstem locomotor centers.;Sharma Sandeep, Kim Linda H, Mayr Kyle A, Elliott David A, Whelan Patrick J, ;2018;Scientific reports;8;6218; 29789702
- A ventrolateral medulla-midline thalamic circuit for hypoglycemic feeding.;Sofia Beas B, Gu Xinglong, Leng Yan, Koita Omar, Rodriguez-Gonzalez Shakira, Kindel Morgan, Matikainen-Ankney Bridget A, Larsen Rylan S, Kravitz Alexxai V, Hoon Mark A, Penzo Mario A, ;2020;Nature communications;11;4811-4833; 33277492
- Direct Parabrachial-Cortical Connectivity.;Grady Fillan, Peltekian Lila, Iverson Gabrielle, Geerling Joel C, ;2020;Cerebral cortex (New York, N.Y. : 1991);30;198; 32383444
- Chemogenetic activation of locus coeruleus neurons ameliorates the severity of multiple sclerosis.;Torrillas-de la Cal Alejandro, Torres-Sanchez Sonia, Bravo Lidia, Llorca-Torralba Meritxell, Garcia-Partida Jose Antonio, Arroba Ana I, Berrocoso Esther, ;2023;Journal of neuroinflammation;20;e3002160; 37658434
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- FGF21 acts in the brain to drive macronutrient-specific changes in behavioral motivation and brain reward signaling.;Khan Md Shahjalal H, Kim Sora Q, Ross Robert C, Corpodean Florina, Spann Redin A, Albarado Diana A, Fernandez-Kim Sun O, Clarke Blaise, Berthoud Hans-Rudolf, Münzberg Heike, McDougal David H, He Yanlin, Yu Sangho, Albaugh Vance L, Soto Paul, Morrison Christopher D, ;2024;bioRxiv : the preprint server for biology;0;; 38798313