Available to order

International strain nameB6;129S5-Gnb1lGt(OST35527)Lex/Orl
Alternative nameLEXKO-443
Strain typeGene-trap
Allele/Transgene symbolGnb1lGt(OST35527)Lex,
Gene/Transgene symbolGnb1l

Information from provider

Provider Lexicon Genetics, Inc.
Provider affiliationLexicon Pharmaceuticals
Phenotypic informationThe mutation resulted in lethality to homozygous mutant mice during early gestation. Total bilirubin levels were elevated in half of the heterozygous mice and were in the high range for the majority of the remaining (-/+) animals. Microscopic analysis revealed membranous glomerulonephritis and lymphoid depletion of splenic lymphoid follicles in the (-/+) mice. Due to embryonic lethality, transcript expression analysis was not performed.
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

MGI phenotypes (allele matching)
  • decreased prepulse inhibition / MGI
  • glomerulonephritis / MGI
  • increased circulating bilirubin level / MGI
  • abnormal spleen B cell follicle morphology / MGI
  • prenatal lethality, complete penetrance / MGI

Information on how we integrate external resources can be found here



Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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