B6.FVB-Tg(Camk2a-cre/ERT2)2Gsc/Ieg

Status

Available to order

EMMA IDEM:02125
International strain nameB6.FVB-Tg(Camk2a-cre/ERT2)2Gsc/Ieg
Alternative nameCaMKCreERT2
Strain typeTransgenic Strains
Allele/Transgene symbolTg(Camk2a-cre/ERT2)2Gsc,
Gene/Transgene symbolTg(Camk2a-cre/ERT2)2Gsc

Information from provider

ProviderGünther Schütz
Provider affiliationMolecular Biology of the Cell I, German Cancer Research Center
Genetic informationcre/ERT2 (or CreESR1; tamoxifen-inducible) recombinase placed under control of the mouse Camk2a (CaMKIIalpha) gene regulatory elements in a BAC vector.
Phenotypic informationNone.
References
  • Inducible gene inactivation in neurons of the adult mouse forebrain.;Erdmann Gitta, Schütz Günther, Berger Stefan, ;2007;BMC neuroscience;8;63; 17683525
  • Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis.;Nordström Viola, Willershäuser Monja, Herzer Silke, Rozman Jan, von Bohlen Und Halbach Oliver, Meldner Sascha, Rothermel Ulrike, Kaden Sylvia, Roth Fabian C, Waldeck Clemens, Gretz Norbert, de Angelis Martin Hrabě, Draguhn Andreas, Klingenspor Martin, Gröne Hermann-Josef, Jennemann Richard, ;2013;PLoS biology;11;e1001506; 23554574

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivingheterozygous C57BL/6N

Literature references

  • Inducible gene inactivation in neurons of the adult mouse forebrain.;Erdmann Gitta, Schütz Günther, Berger Stefan, ;2007;BMC neuroscience;8;63; 17683525
  • Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis.;Nordström Viola, Willershäuser Monja, Herzer Silke, Rozman Jan, von Bohlen Und Halbach Oliver, Meldner Sascha, Rothermel Ulrike, Kaden Sylvia, Roth Fabian C, Waldeck Clemens, Gretz Norbert, de Angelis Martin Hrabě, Draguhn Andreas, Klingenspor Martin, Gröne Hermann-Josef, Jennemann Richard, ;2013;PLoS biology;11;e1001506; 23554574
  • Prox1 postmitotically defines dentate gyrus cells by specifying granule cell identity over CA3 pyramidal cell fate in the hippocampus.;Iwano Tomohiko, Masuda Aki, Kiyonari Hiroshi, Enomoto Hideki, Matsuzaki Fumio, ;2012;Development (Cambridge, England);139;3051-62; 22791897
  • A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex.;Li Min-Yin, Miao Wan-Ying, Wu Qiu-Zi, He Shun-Ji, Yan Guoquan, Yang Yanrui, Liu Jia-Jia, Taketo M Mark, Yu Xiang, ;2017;Neuron;94;1155-1172.e8; 28641114
  • Adult Deletion of SRF Increases Epileptogenesis and Decreases Activity-Induced Gene Expression.;Kuzniewska Bozena, Nader Karolina, Dabrowski Michal, Kaczmarek Leszek, Kalita Katarzyna, ;2016;Molecular neurobiology;53;1478-1493; 25636686
  • Sonic hedgehog is a regulator of extracellular glutamate levels and epilepsy.;Feng Shengjie, Ma Shaorong, Jia Caixia, Su Yujuan, Yang Shenglian, Zhou Kechun, Liu Yani, Cheng Ju, Lu Dunguo, Fan Liu, Wang Yizheng, ;2016;EMBO reports;17;682-94; 27113760
  • Huntingtin acts non cell-autonomously on hippocampal neurogenesis and controls anxiety-related behaviors in adult mouse.;Pla Patrick, Orvoen Sophie, Benstaali Caroline, Dodier Sophie, Gardier Alain M, David Denis J, Humbert Sandrine, Saudou Frédéric, ;2013;PloS one;8;e73902; 24019939
  • Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons.;Oettinghaus B, Schulz J M, Restelli L M, Licci M, Savoia C, Schmidt A, Schmitt K, Grimm A, Morè L, Hench J, Tolnay M, Eckert A, D'Adamo P, Franken P, Ishihara N, Mihara K, Bischofberger J, Scorrano L, Frank S, ;2016;Cell death and differentiation;23;18-28; 25909888
  • Clock-Controlled Mitochondrial Dynamics Correlates with Cyclic Pregnenolone Synthesis.;Witzig Melissa, Grimm Amandine, Schmitt Karen, Lejri Imane, Frank Stephan, Brown Steven A, Eckert Anne, ;2020;Cells;9;; 33086741

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).