Available to order

International strain nameB6Rcc.Cg-KitW/Cnrm
Alternative nameC57 BL/6RCC c-kitW
Strain typeSpontaneous
Allele/Transgene symbolKitW,
Gene/Transgene symbolKit

Information from provider

ProviderUrsula Günthert
Provider affiliationInstitut für Pathologie, University of Basel
Genetic informationThe KitW (KIT proto-oncogene; dominant spotting) allele, is a spontaneous mutation in the Kit (Cd117) gene which involves a G to A nucleotide exchange affecting the splice donor site of intron 10. This causes skipping of exon 10, the exon encoding the transmembrane domain, resulting in a protein that can not be expressed on the cell surface.
Phenotypic informationCd117-/-: Macrocytic anaemia, reduced red blood cells number with increased volume. Homozygous mice die at day 10 after birth.
Breeding history10 generations backcrossed onto C57BL/6Rcc; currently bred as C57BL/6Rcc Cd117 +/-.
  • Prevention of genetic anemias in mice by microinjection of normal hematopoietic stem cells into the fetal placenta.;Fleischman R A, Mintz B, ;1979;Proceedings of the National Academy of Sciences of the United States of America;76;5736-40; 42904

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal ventral coat pigmentation / MGI
  • decreased mast cell number / MGI
  • abnormal mast cell physiology / MGI
  • absent coat pigmentation / MGI
  • small ovary / MGI
  • small testis / MGI
  • abnormal spermatogenesis / MGI
  • infertility / MGI
  • abnormal ovarian follicle number / MGI
  • high mean erythrocyte cell number / MGI
  • increased hematocrit / MGI
  • irregular coat pigmentation / MGI
  • abnormal coat/hair pigmentation / MGI
  • variable body spotting / MGI
  • reproductive system phenotype / MGI
  • hematopoietic system phenotype / MGI
  • decreased body weight / MGI
  • prenatal lethality / MGI
  • macrocytic anemia / MGI
  • abnormal survival / MGI
  • perinatal lethality, incomplete penetrance / MGI
  • abnormal eye pigmentation / MGI
  • postnatal lethality, complete penetrance / MGI
  • altered response to myocardial infarction / MGI
  • kidney inflammation / MGI
  • decreased inflammatory response / MGI
  • decreased airway responsiveness / MGI
  • increased urine protein level / MGI
  • increased myocardial infarction size / MGI
  • decreased vascular permeability / MGI
  • abnormal response/metabolism to endogenous compounds / MGI
  • abnormal renal glomerulus morphology / MGI
  • immune system phenotype / MGI
  • impaired neutrophil recruitment / MGI
  • abnormal interferon level / MGI
  • abnormal interleukin level / MGI
  • increased sensitivity to induced morbidity/mortality / MGI
  • increased erythrocyte protoporphyrin level / MGI
  • glomerular crescent / MGI
  • abnormal Sertoli cell morphology / MGI
  • abnormal histamine physiology / MGI
  • decreased susceptibility to induced arthritis / MGI
  • abnormal body temperature / MGI
  • decreased susceptibility to type I hypersensitivity reaction / MGI
  • decreased basophil cell number / MGI
  • hepatic steatosis / MGI
  • preweaning lethality, incomplete penetrance / MGI
  • increased papilloma incidence / MGI
  • increased esophageal papilloma incidence / MGI
  • peptic ulcer / MGI
  • abnormal response to transplant / MGI
  • abnormal digestive system physiology / MGI
  • abnormal muscle physiology / MGI
  • abnormal interstitial cell of Cajal morphology / MGI
  • increased sensitivity to xenobiotic induced morbidity/mortality / MGI
  • prenatal lethality, complete penetrance / MGI

Literature references

  • Prevention of genetic anemias in mice by microinjection of normal hematopoietic stem cells into the fetal placenta.;Fleischman R A, Mintz B, ;1979;Proceedings of the National Academy of Sciences of the United States of America;76;5736-40; 42904

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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