B6;129P2-Prmt2tm1Yah Cstbtm1Yah/+ +/Orl

Status

Available to order

EMMA IDEM:01810
Citation informationRRID:IMSR_EM:01810 

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International strain nameB6;129P2-Prmt2tm1Yah Cstbtm1Yah/+ +/Orl
Alternative nameCis (Hrmt1l1tm1Yah-Cstbtm1Yah)
Strain typeTargeted Mutant Strains : Other targeted
Allele/Transgene symbolPrmt2tm1Yah, Cstbtm1Yah
Gene/Transgene symbolPrmt2, Cstb

Information from provider

ProviderYann HERAULT
Provider affiliationTAAM-CDTA UPS44, Institut de Transgenose, INTRAGENE
Genetic informationInsertion by homologous recombination in ES cells using MICER of a targeting vector containing a loxP site at the Hrmt1l1 (Prmt2) locus and of a second vector, on the same homologous chromosome, containing a loxP site at the Cstb locus (cis configuration of the loxP sites on MMU10).
Phenotypic informationNo visible phenotype.
Breeding historyTargeted mutation generated in 129P2 ES cells. Cells injected in C57BL/6 blastocysts. Backcrossed to C57BL/6, then intercrossed.
References
  • Inducing segmental aneuploid mosaicism in the mouse through targeted asymmetric sister chromatid event of recombination.;Duchon Arnaud, Besson Vanessa, Pereira Patricia Lopes, Magnol Laetitia, Hérault Yann, ;2008;Genetics;180;51-9; 18757940

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • decreased body length / IMPC
  • increased monocyte cell number / IMPC
  • abnormal auditory brainstem response / IMPC
  • decreased total retina thickness / IMPC
  • abnormal eye anterior chamber depth / IMPC
  • abnormal retina outer nuclear layer morphology / IMPC
  • decreased lymphocyte cell number / IMPC
  • hyperactivity / IMPC
  • increased vertical activity / IMPC
  • short tibia / IMPC
  • increased circulating triglyceride level / IMPC
  • decreased circulating creatinine level / IMPC
MGI phenotypes (allele matching)
  • nervous system phenotype / MGI
  • behavior/neurological phenotype / MGI
MGI phenotypes (gene matching)
  • myoclonus / MGI
  • abnormal cerebellum morphology / MGI
  • cerebellum hypoplasia / MGI
  • abnormal cornea morphology / MGI
  • increased incidence of corneal inflammation / MGI
  • corneal opacity / MGI
  • corneal scarring / MGI
  • ataxia / MGI
  • impaired coordination / MGI
  • abnormal gait / MGI
  • abnormal apoptosis / MGI
  • seizures / MGI
  • nervous system phenotype / MGI
  • abnormal nervous system physiology / MGI
  • abnormal cerebellar granule cell morphology / MGI
  • abnormal brain wave pattern / MGI
  • abnormal eye physiology / MGI
  • growth/size/body region phenotype / MGI
  • behavior/neurological phenotype / MGI
  • uveitis / MGI
  • facial muscle spasm / MGI
  • abnormal cell cycle / MGI
  • abnormal vascular wound healing / MGI
  • increased sacral vertebrae number / MGI

Literature references

  • Inducing segmental aneuploid mosaicism in the mouse through targeted asymmetric sister chromatid event of recombination.;Duchon Arnaud, Besson Vanessa, Pereira Patricia Lopes, Magnol Laetitia, Hérault Yann, ;2008;Genetics;180;51-9; 18757940

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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