Available to order

International strain nameB6.Cg-Gt(ROSA)26Sortm1.1(Ubc-Grn)Ite/Ieg
Alternative nameGt(ROSA)26Sortm1.1(Ubc-Grn)Ite MGI:6149573
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolGt(ROSA)26Sortm1.1(Ubc-Grn)Ite,
Gene/Transgene symbolGt(ROSA)26Sor

Information from provider

ProviderIrmgard Tegeder
Provider affiliationClinical Pharmacology, Goethe University Frankfurt, Faculty of Medicine
Genetic informationA ubiquitin C promoter, a floxed stop cassette, mouse progranulin cDNA, and FRT flanked pgk-neo cassette were inserted via homologous recombination into the Gt(ROSA)26Sor locus. Flp mediated recombination removed the neo cassette. See reference: Altmann C, et al., Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy. Neurobiol Dis. 2016 Dec;96:294- 311. doi: 10.1016/j.nbd.2016.09.010. Epub 2016 Sep 11. PMID: 27629805
Phenotypic informationHomozygous:

Breeding historyParent ES cell line: Bruce 4, strain of origin: B6.Cg-Thy1a. Crossed with C57BL/6. Bred as homozygous line (Grn-flfl) since 2015.
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredyes

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivinghomozygous C57BL/6

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

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* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Example health report
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Material Transfer Agreement (MTA)
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EMMA conditions
Legally binding conditions for the transfer

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