B6.Cg-Gt(ROSA)26Sortm1.1(Ubc-Grn)Ite/Ieg
Status | Available to order |
EMMA ID | EM:15254 |
International strain name | B6.Cg-Gt(ROSA)26Sortm1.1(Ubc-Grn)Ite/Ieg |
Alternative name | Gt(ROSA)26Sortm1.1(Ubc-Grn)Ite MGI:6149573 |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Gt(ROSA)26Sortm1.1(Ubc-Grn)Ite, |
Gene/Transgene symbol | Gt(ROSA)26Sor |
Information from provider
Provider | Irmgard Tegeder |
Provider affiliation | Clinical Pharmacology, Goethe University Frankfurt, Faculty of Medicine |
Genetic information | A ubiquitin C promoter, a floxed stop cassette, mouse progranulin cDNA, and FRT flanked pgk-neo cassette were inserted via homologous recombination into the Gt(ROSA)26Sor locus; flp-mediated recombination removed the neo cassette. See reference: Altmann C, et al., Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy. Neurobiol Dis. 2016 Dec;96:294- 311. doi: 10.1016/j.nbd.2016.09.010. Epub 2016 Sep 11. PMID: 27629805 |
Phenotypic information | Homozygous:NoneHeterozygous:None |
Breeding history | Parent ES cell line: Bruce 4, strain of origin: B6.Cg-Thy1a. Crossed with C57BL/6. Bred as homozygous line (Grn-flfl) since 2015. |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | yes |
Immunocompromised | no |
Information from EMMA
Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Animals used for archiving | homozygous C57BL/6 |
Literature references
- Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy.;Altmann Christine, Hardt Stefanie, Fischer Caroline, Heidler Juliana, Lim Hee-Young, Häussler Annett, Albuquerque Boris, Zimmer Béla, Möser Christine, Behrends Christian, Koentgen Frank, Wittig Ilka, Schmidt Mirko H H, Clement Albrecht M, Deller Thomas, Tegeder Irmgard, ;2016;Neurobiology of disease;96;294-311; 27629805
- Loss of synaptic zinc transport in progranulin deficient mice may contribute to progranulin-associated psychopathology and chronic pain.;Hardt Stefanie, Heidler Juliana, Albuquerque Boris, Valek Lucie, Altmann Christine, Wilken-Schmitz Annett, Schäfer Michael K E, Wittig Ilka, Tegeder Irmgard, ;2017;Biochimica et biophysica acta. Molecular basis of disease;1863;2727-2745; 28720486
- Progranulin deficiency confers resistance to autoimmune encephalomyelitis in mice.;Schmitz Katja, Wilken-Schmitz Annett, Vasic Verica, Brunkhorst Robert, Schmidt Mirko, Tegeder Irmgard, ;2020;Cellular & molecular immunology;17;1077-1091; 31467413
- Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling.;Altmann Christine, Vasic Verica, Hardt Stefanie, Heidler Juliana, Häussler Annett, Wittig Ilka, Schmidt Mirko H H, Tegeder Irmgard, ;2016;Molecular neurodegeneration;11;69; 27770818
- Increased Fat Taste Preference in Progranulin-Deficient Mice.;Schumann Lana, Wilken-Schmitz Annett, Trautmann Sandra, Vogel Alexandra, Schreiber Yannick, Hahnefeld Lisa, Gurke Robert, Geisslinger Gerd, Tegeder Irmgard, ;2021;Nutrients;13;; 34836380
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