B6.Cg-Tg(Bmx-cre/ERT2)1Rha/H

Status

Available to order

EMMA IDEM:15026
International strain nameB6.Cg-Tg(Bmx-cre/ERT2)1Rha/H
Alternative nameC57BL/6J-Tg(Bmx-cre/ERT2)1Rha
Strain typeTransgenic Strains
Allele/Transgene symbolTg(Bmx-cre/ERT2)1Rha,
Gene/Transgene symbolTg(Bmx-cre/ERT2)1Rha

Information from provider

ProviderRalph H Adams
Provider affiliationMax Planck Institute for Molecular Biomedicine
Genetic informationAn inducible cre deleter under the control of the BMX non-receptor tyrosine kinase promoter. Cre recombination is inducible via administration of tamoxifen. Useful for study of angiogenesis, atherosclerosis and neovascularization. Non-induced Bmx-CreERT2 mice demonstrate no Cre recombinase activity, while tamoxifen-induced Bmx-CreERT2 mice demonstrate high levels of recombinase-mediated gene deletion in endothelial cells (95%+).
Phenotypic informationHomozygous:
Not known

Heterozygous:
Normal appearance
Breeding historyFounder lines were backcrossed to C57BL/6 for at least five generations.
References
  • Notch controls retinal blood vessel maturation and quiescence.;Ehling Manuel, Adams Susanne, Benedito Rui, Adams Ralf H, ;2013;Development (Cambridge, England);140;3051-61; 23785053
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Literature references

  • Notch controls retinal blood vessel maturation and quiescence.;Ehling Manuel, Adams Susanne, Benedito Rui, Adams Ralf H, ;2013;Development (Cambridge, England);140;3051-61; 23785053

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