C57BL/6J-Taf1em2Ems/H
| Status | Available to order |
| EMMA ID | EM:14890 |
| International strain name | C57BL/6J-Taf1em2Ems/H |
| Alternative name | C57BL/6J-Taf1em2Ems/Mmjax |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Taf1em2Ems |
| Gene/Transgene symbol | Taf1 |
Information from provider
| Provider | Elizabeth Fisher |
| Provider affiliation | Institute of Neurology, University College London |
| Additional owner | Dr Elizabeth Simpson, University of British Columbia, Canada. |
| Genetic information | Conditional knock-out of the mouse Taf1 gene which maps to the X chromosome. Produced by CRISPR knock-in of two loxP sites, flanking exon 8 (with respect to transcripts Taf1-202 or -206) or exons 8-9 (with respect to transcript Taf1-201). CRISPR technology details: the Cas9 nuclease was used and it has not been integrated in the mouse genome. |
| Phenotypic information | Homozygous:No discernible phenotype, in mice not bred to cre recombinase-expressing transgenics.Heterozygous:Apparently like wild-type. |
| Breeding history | At least N2 on C57BL/6J. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Taf1 knockout is lethal in embryonic male mice and heterozygous females show weight and movement disorders.;Crombie Elisa M, Korecki Andrea J, Cleverley Karen, Adair Bethany A, Cunningham Thomas J, Lee Weaverly Colleen, Lengyell Tess C, Maduro Cheryl, Mo Victor, Slade Liam M, Zouhair Ines, Fisher Elizabeth M C, Simpson Elizabeth M, ;2024;Disease models & mechanisms;17;; 38804708