C57BL/6N-Tg(Prnp-SNCA*)11Ccs/Ieg
| Status | Available to order |
| EMMA ID | EM:14609 |
| International strain name | C57BL/6N-Tg(Prnp-SNCA*)11Ccs/Ieg |
| Alternative name | C57BL/6N-Tg(Prnp-Snca11Hlu) |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Prnp-SNCA*)11Ccs |
| Gene/Transgene symbol | Tg(Prnp-SNCA*)11Ccs |
Information from provider
| Provider | Xinran Zhu |
| Provider affiliation | Tierphysiologie, Biologie, Ruhr-Universität Bochum |
| Genetic information | Prnp-Snca transgenic mice express the human alpha-synuclein gene with two missense mutations (A53T and A30P) under the direction of the mouse prion protein promoter. |
| Phenotypic information | Homozygous:Homozygous mice have not been established yetHeterozygous:Transgenic mice were viable, fertile, and showed no gross anatomical or neuronal abnormalities. Dopaminergic neuron (DA) numbers in the substantia nigra and fiber densities and dopamine levels in the striatum were normal |
| Breeding history | The construct was microinjected into fertilized C57BL/6N oocytes and the founder line 11 were bred to C57BL/6N to establish the colony. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6N |
Literature references
- Influence of different promoters on the expression pattern of mutated human alpha-synuclein in transgenic mice.;Maskri Lyutha, Zhu XinRan, Fritzen Sabrina, Kühn Kati, Ullmer Christoph, Engels Peter, Andriske Michael, Stichel Christine C, Lübbert Hermann, ;2004;Neuro-degenerative diseases;1;255-65; 16908976