B6J.B6N(Cg)-Rps6ka5tm1.1Arte/H
| Status | Available to order |
| EMMA ID | EM:13015 |
| Citation information | RRID:IMSR_EM:13015 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6J.B6N(Cg)-Rps6ka5tm1.1Arte/H |
| Alternative name | MSK1 Kinase Dead (MSK1 KD) |
| Strain type | Targeted Mutant Strains : Point mutation |
| Allele/Transgene symbol | Rps6ka5tm1.1Arte |
| Gene/Transgene symbol | Rps6ka5 |
Information from provider
| Provider | Simon Arthur |
| Provider affiliation | School of Life Sciences, University of Dundee |
| Genetic information | A kinase-dead MSK1 mouse was generated by mutating Asp194 to Ala in the endogenous MSK1 (Rps6ka5) gene. The knock-in was produced by TaconicArtemis using standard targeting methods in C57BL/6 ES cells. |
| Phenotypic information | Homozygous:Mice have impaired hippocampal synaptic transmission and greater dendritic spine density (CA1), but no obvious behavioural or LTP/LTD phenotype.Heterozygous:Not tested. |
| Breeding history | Mice originally derived from C57BL/6N have been backcrossed with C57BL/6J for at least 6 generations. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- MSK1 regulates transcriptional induction of Arc/Arg3.1 in response to neurotrophins.;Hunter Chris J, Remenyi Judit, Correa Sonia A, Privitera Lucia, Reyskens Kathleen M S E, Martin Kirsty J, Toth Rachel, Frenguelli Bruno G, Arthur J Simon C, ;2017;FEBS open bio;7;821-834; 28593137
- MSK1 regulates homeostatic and experience-dependent synaptic plasticity.;Corrêa Sonia A L, Hunter Christopher J, Palygin Oleg, Wauters Sandrine C, Martin Kirsty J, McKenzie Colin, McKelvey Kim, Morris Richard G M, Pankratov Yuriy, Arthur J Simon C, Frenguelli Bruno G, ;2012;The Journal of neuroscience : the official journal of the Society for Neuroscience;32;13039-51; 22993422
- The Kinase Function of MSK1 Regulates BDNF Signaling to CREB and Basal Synaptic Transmission, But Is Not Required for Hippocampal Long-Term Potentiation or Spatial Memory.;Daumas Stephanie, Hunter Christopher J, Mistry Rajen B, Morè Lorenzo, Privitera Lucia, Cooper Daniel D, Reyskens Kathleen M, Flynn Harry T, Morris Richard G M, Arthur J Simon C, Frenguelli Bruno G, ;2017;eNeuro;4;4644-4660; 28275711
- Experience Recruits MSK1 to Expand the Dynamic Range of Synapses and Enhance Cognition.;Privitera Lucia, Morè Lorenzo, Cooper Daniel D, Richardson Philippa, Tsogka Marianthi, Hebenstreit Daniel, Arthur J Simon C, Frenguelli Bruno G, ;2020;The Journal of neuroscience : the official journal of the Society for Neuroscience;40;6031-6072; 32376781
- MSK1 is required for the beneficial synaptic and cognitive effects of enriched experience across the lifespan.;Morè Lorenzo, Privitera Lucia, Cooper Daniel D, Tsogka Marianthi, Arthur J Simon C, Frenguelli Bruno G, ;2023;Aging;15;110110; 37432063
- MSK1 is required for the experience- and ampakine-dependent enhancement of spatial reference memory and reversal learning and for the induction of Arc and BDNF.;Morè Lorenzo, Privitera Lucia, Lopes Marcia, Arthur J Simon C, Lauterborn Julie C, Corrêa Sonia A L, Frenguelli Bruno G, ;2024;Neuropharmacology;261;; 39128584