C57BL/6NCrl-Tg(Vav1-STAT5B)731Biat/Biat

Status

Available to order

EMMA IDEM:12476
International strain nameC57BL/6NCrl-Tg(Vav1-STAT5B)731Biat/Biat
Alternative nameB6N-Tg(STAT5B)731Biat
Strain typeTransgenic Strains
Allele/Transgene symbolTg(Vav1-STAT5B)731Biat
Gene/Transgene symbolTg(Vav1-STAT5B)731Biat

Information from provider

ProviderRichard Moriggl
Provider affiliationDepartment for Biomedical Sciences, University of Veterinary Medicine, Vienna (Vetmeduni Vienna)
Genetic informationTransgenic mice were generated and bred on a C57BL/6NCrl background. We used the Vav1-hematopoietic vector Vav1-hCD4 (HS21/45) to generate several transgenic mouse lines expressing hSTAT5B and hSTAT5BN642H in the hematopoietic system and selected the lines B6N-Tg(STAT5B)731Biat (this one, EMMA ID EM:12476) and B6N-Tg(STAT5BN/H)726Biat (EMMA ID EM:12475), respectively, for further experiments. The hSTAT5BN642H construct was generated using overlapping PCR technology.
Phenotypic informationHomozygous:
Unknown.

Heterozygous:
No obvious phenotype; therefore the strain is used as a control for strain hSTAT5BN642H (EM:12475).
Breeding history>10 generations of backcross.
References
  • STAT5BN642H is a driver mutation for T cell neoplasia.;Pham Ha Thi Thanh, Maurer Barbara, Prchal-Murphy Michaela, Grausenburger Reinhard, Grundschober Eva, Javaheri Tahereh, Nivarthi Harini, Boersma Auke, Kolbe Thomas, Elabd Mohamed, Halbritter Florian, Pencik Jan, Kazemi Zahra, Grebien Florian, Hengstschläger Markus, Kenner Lukas, Kubicek Stefan, Farlik Matthias, Bock Christoph, Valent Peter, Müller Mathias, Rülicke Thomas, Sexl Veronika, Moriggl Richard, ;2018;The Journal of clinical investigation;128;387-401; 29200404
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria
Animals used for archivingheterozygous C57BL/6N

Literature references

  • STAT5BN642H is a driver mutation for T cell neoplasia.;Pham Ha Thi Thanh, Maurer Barbara, Prchal-Murphy Michaela, Grausenburger Reinhard, Grundschober Eva, Javaheri Tahereh, Nivarthi Harini, Boersma Auke, Kolbe Thomas, Elabd Mohamed, Halbritter Florian, Pencik Jan, Kazemi Zahra, Grebien Florian, Hengstschläger Markus, Kenner Lukas, Kubicek Stefan, Farlik Matthias, Bock Christoph, Valent Peter, Müller Mathias, Rülicke Thomas, Sexl Veronika, Moriggl Richard, ;2018;The Journal of clinical investigation;128;387-401; 29200404

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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