B6J.B6N(Cg)-Pomt1tm1c(EUCOMM)Hmgu/Cnbc

Status

Available to order

EMMA IDEM:12210
International strain nameB6J.B6N(Cg)-Pomt1tm1c(EUCOMM)Hmgu/Cnbc
Alternative namePomt1tm1c(EUCOMM)/Jec
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolPomt1tm1c(EUCOMM)Hmgu
Gene/Transgene symbolPomt1

Information from provider

ProviderJesús Cruces
Provider affiliationBioquímica, Universidad Autónoma de Madrid
Genetic informationFloxed Pomt1 allele for exons 3 and 4, following EUCOMM strategy.
Phenotypic informationHomozygous:
No phenotypic expression

Heterozygous:
No phenotypic description
Breeding historyChimera were crossed with CD1 to obtain F1. F1 were crossed with flippase transgenic mice. Mice obtained were crossed more than 10 times with C57BL/6J mice.
References
  • Impairment of photoreceptor ribbon synapses in a novel Pomt1 conditional knockout mouse model of dystroglycanopathy.;Rubio-Fernández Marcos, Uribe Mary Luz, Vicente-Tejedor Javier, Germain Francisco, Susín-Lara Cristina, Quereda Cristina, Montoliu Lluis, de la Villa Pedro, Martín-Nieto José, Cruces Jesús, ;2018;Scientific reports;8;8543; 29867208
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archivingheterozygous C57BL/6J

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • increased neutrophil cell number / MGI
  • embryonic growth arrest / MGI
  • decreased IgG level / MGI
  • abnormal Reichert's membrane morphology / MGI
  • increased vasodilation / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • preweaning lethality, complete penetrance / MGI

Literature references

  • Impairment of photoreceptor ribbon synapses in a novel Pomt1 conditional knockout mouse model of dystroglycanopathy.;Rubio-Fernández Marcos, Uribe Mary Luz, Vicente-Tejedor Javier, Germain Francisco, Susín-Lara Cristina, Quereda Cristina, Montoliu Lluis, de la Villa Pedro, Martín-Nieto José, Cruces Jesús, ;2018;Scientific reports;8;8543; 29867208

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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