STOCK Egr2tm3Pch Egr3tm1Jmi Tg(CD2-icre)4Kio/H


Available to order

International strain nameSTOCK Egr2tm3Pch Egr3tm1Jmi Tg(CD2-icre)4Kio/H
Alternative nameCD2-Egr2/3 KO mouse
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolEgr3tm1Jmi,
Gene/Transgene symbolEgr3

Information from provider

ProviderSuling Li
Provider affiliationLife Science, Brunel University
Genetic informationEgr3-/- and CD2-specific Egr2-/- (CD2-Egr2-/- Egr3-/-) mice were generated by interbreeding Egr3-/- (Tourtellotte and Milbrandt, 1998) and CD2-specific Egr2 -/- mice (Zhu et al., 2008) on the C57BL/6 background.
Phenotypic informationHomozygous:
The KO mice with deletion of both transcription factors Egr2 and Egr3 in lymphocytes resulted in a lethal autoimmune syndrome with excessive serum proinflammatory cytokines but also impaired antigen receptor-induced proliferation of B and T cells.

Inflammation similar as homozygous but less severe.
Breeding historyC57BL/6 with 129/SvJ
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • decreased rhombomere 3 size / MGI



Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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