B6.129P2(Cg)-Tnfrsf1a^tm3.3Gkl/Flmg

Status	Available to order
EMMA ID	EM:11019
International strain name	B6.129P2(Cg)-Tnfrsf1a^tm3.3Gkl/Flmg
Alternative name	B6.129P2(Cg)-Tnfrsf1a/Flmg
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Tnfrsf1a^tm3.3Gkl,
Gene/Transgene symbol	Tnfrsf1a

Information from provider

Provider	George Kollias
Provider affiliation	BSRC Fleming
Genetic information	An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2. A second loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the selection cassette and left exons 2 through 5 floxed. Cre-mediated recombination, specific to the myeloid lineage, removed exons 2 through 5.
Phenotypic information	Homozygous: No overt phenotype Heterozygous: No overt phenotype
References	Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium.;Van Hauwermeiren Filip, Armaka Marietta, Karagianni Niki, Kranidioti Ksanthi, Vandenbroucke Roosmarijn E, Loges Sonja, Van Roy Maarten, Staelens Jan, Puimège Leen, Palagani Ajay, Berghe Wim Vanden, Victoratos Panayiotis, Carmeliet Peter, Libert Claude, Kollias George, ;2013;The Journal of clinical investigation;123;2590-603; 23676465 Opposing role of tumor necrosis factor receptor 1 signaling in T cell-mediated hepatitis and bacterial infection in mice.;Wroblewski Raluca, Armaka Marietta, Kondylis Vangelis, Pasparakis Manolis, Walczak Henning, Mittrücker Hans-Willi, Schramm Christoph, Lohse Ansgar W, Kollias George, Ehlken Hanno, ;2016;Hepatology (Baltimore, Md.);64;508-21; 26991125
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	B.S.R.C. Alexander Fleming, Vari, Greece
Animals used for archiving	heterozygous C57BL/6

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Tumor necrosis factor receptor 1 associated periodic syndrome / Orphanet_32960

Literature references

Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium.;Van Hauwermeiren Filip, Armaka Marietta, Karagianni Niki, Kranidioti Ksanthi, Vandenbroucke Roosmarijn E, Loges Sonja, Van Roy Maarten, Staelens Jan, Puimège Leen, Palagani Ajay, Berghe Wim Vanden, Victoratos Panayiotis, Carmeliet Peter, Libert Claude, Kollias George, ;2013;The Journal of clinical investigation;123;2590-603; 23676465
Opposing role of tumor necrosis factor receptor 1 signaling in T cell-mediated hepatitis and bacterial infection in mice.;Wroblewski Raluca, Armaka Marietta, Kondylis Vangelis, Pasparakis Manolis, Walczak Henning, Mittrücker Hans-Willi, Schramm Christoph, Lohse Ansgar W, Kollias George, Ehlken Hanno, ;2016;Hepatology (Baltimore, Md.);64;508-21; 26991125

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.

B6.129P2(Cg)-Tnfrsf1atm3.3Gkl/Flmg