MGI phenotypes (allele matching)
STOCK Vegfctm1Ali/Oulu
| Status | Available to order |
| EMMA ID | EM:10734 |
| Citation information | RRID:IMSR_EM:10734 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Vegfctm1Ali/Oulu |
| Alternative name | VEGFC/LacZ |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Vegfctm1Ali |
| Gene/Transgene symbol | Vegfc |
Information from provider
| Provider | Kari Alitalo |
| Provider affiliation | Translational Cancer Biology Research Program; Institute of Biomedicine, University of Helsinki |
| Genetic information | Vegfc has been replaced with a lacZ and neo cassette inserted by homologous recombination. |
| Phenotypic information | Homozygous:Not viable, die around E16-E17.Heterozygous:Those heterozygous mice that survive until weaning are viable and fertile. Surviving rate to this point is relatively poor and background dependent. |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
| Animals used for archiving | heterozygous males |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Milroy disease / Orphanet_79452
- Congenital primary lymphedema of Gordon / Orphanet_569821
MGI phenotypes (gene matching)
Literature references
- Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins.;Karkkainen Marika J, Haiko Paula, Sainio Kirsi, Partanen Juha, Taipale Jussi, Petrova Tatiana V, Jeltsch Michael, Jackson David G, Talikka Marja, Rauvala Heikki, Betsholtz Christer, Alitalo Kari, ;2004;Nature immunology;5;74-80; 14634646