C57BL/6J-Tg(Pax8-cre/ERT2)CAmat/AmatH
| Status | Available to order |
| EMMA ID | EM:10364 |
| International strain name | C57BL/6J-Tg(Pax8-cre/ERT2)CAmat/AmatH |
| Alternative name | Pax8-CreERT2 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Pax8-cre/ERT2)CAmat |
| Gene/Transgene symbol | Tg(Pax8-cre/ERT2)CAmat |
Information from provider
| Provider | Athena Matakidou |
| Provider affiliation | University of Cambridge CRUK Cambridge Institute |
| Genetic information | Transgenic mouse expressing a CreERT2 cassette from the mouse Pax8 promoter (4.3kb of upstream regulatory sequence, complete exon 1 and intron 1, part of exon 2 and 0.8kb of intron 2 of the murine Pax8 gene). Upon tamoxifen administration Cre recombinase is exclusively expressed in renal tubular epithelia (proximal and distal tubules as well as collecting ducts). |
| Phenotypic information | Heterozygous and homozygous Pax8-CreERT2 mice are viable and display no discernible phenotype. Upon tamoxifen administration Cre recombinase is exclusively expressed in renal tubular epithelia (proximal and distal tubules as well as collecting ducts). |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Generation and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells.;Espana-Agusti Judit, Zou Xiangang, Wong Kim, Fu Beiyuan, Yang Fengtang, Tuveson David A, Adams David J, Matakidou Athena, ;2016;PloS one;11;e0148055; 26866916