B6J.Cg-Tg(Thy1-MAPT*P301S)2541Godt/H
| Status | Available to order |
| EMMA ID | EM:15269 |
| International strain name | B6J.Cg-Tg(Thy1-MAPT*P301S)2541Godt/H |
| Alternative name | Tg(Thy1-MAPT*P301S)2541Godt |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Thy1-MAPT*P301S)2541Godt |
| Gene/Transgene symbol | Tg(Thy1-MAPT*P301S)2541Godt |
Information from provider
| Provider | Michel Goedert |
| Provider affiliation | MRC Laboratory of Molecular Biology |
| Genetic information | Homozygous for human 0N4R P301S Tau (MAPT) transgene (under Thy1.2 promoter). |
| Phenotypic information | Homozygous:Progressive impaired gait culminating in hindlimb paralysis around 7-8 months of age.Heterozygous:Same as for homozygous mice but delayed and with a wider window. Heterozygous mice usually reach end point between 12 and 20 months of age. |
| Breeding history | More than 10 backcrosses onto C57BL/6J background. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein.;Allen Bridget, Ingram Esther, Takao Masaki, Smith Michael J, Jakes Ross, Virdee Kanwar, Yoshida Hirotaka, Holzer Max, Craxton Molly, Emson Piers C, Atzori Cristiana, Migheli Antonio, Crowther R Anthony, Ghetti Bernardino, Spillantini Maria Grazia, Goedert Michel, ;2002;The Journal of neuroscience : the official journal of the Society for Neuroscience;22;9340-51; 12417659