Systemic Phenotyping by the Institut Clinique de la Souris

The Institut Clinique de la Souris (ICS)

The ICS, with dedicated areas for mouse and rat breeding and phenotyping, provides comprehensive services to meet the diverse needs of researchers. The animal facility includes space for breeding 15k mouse cages and 300 rat cages, as well as dedicated phenotyping areas with a capacity of 2k mouse cages and 135 rat cages. The facility, nestled in Illkirch, France, stands near the renowned Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC). Being part of this esteemed scientific institute offers numerous advantages for researchers. Collaborating with IGBMC fosters interdisciplinary interactions and access to a wealth of expertise in genetics, molecular biology, and cellular biology.

Service Description:

The ICS is a leading provider of comprehensive preclinical phenotyping services for mouse and rat models. A wide array of services encompasses neurobiology and behaviour assessments, cardiovascular system evaluations, clinical chemistry, and hematology profiling, metabolic exploration, histopathology, embryology, and oncology studies. These services play a crucial role in understanding disease mechanisms, evaluating therapeutic interventions, and advancing translational research. Leveraging ICS’s expertise and state-of-the-art facilities, they deliver actionable insights into the physiological, pathological, and molecular aspects of animal models, empowering researchers to make meaningful scientific discoveries and accelerate the development of novel therapies.

Included in the Service:

ICS’s service provision is highly flexible, offering both standardised and customisable protocols, à la carte options to suit the specific needs of each research project. With a team of dedicated project managers overseeing each study, researchers benefit from a single point of contact for seamless coordination and efficient project tracking. Additionally, the facility is ISO9001 certified and adheres to the NFX 50-900 standard, ensuring the highest level of quality and consistency in our services. ICS also provides expertise in utilising adeno-associated viruses (AAVs), compounds, and small molecules in experimental designs. The services provided encompass comprehensive data analysis using state-of-the-art methods, and delivery of detailed, interpretive reporting of findings, empowering researchers with actionable insights to drive their scientific discoveries forward effectively.

Additional Support

Under the same roof, ICS team of experts specialises in designing and creating genetically modified rats and mice using the latest technologies. From conceptualising mutation ideas to conducting phenotyping studies, they provide end-to-end solutions to meet your research objectives effectively. Furthermore, ICS’s state-of-the-art animal facility is equipped to handle large-scale projects and offers animal services ensuring the availability and preservation of valuable animal models for future studies (cryopreservation, IVF..).

Relevant Publications

  1. AJimenez-Armijo A, Morkmued S, Ahumada JT, et al. The Rogdi knockout mouse is a model for Kohlschütter-Tönz syndrome. Sci Rep. 2023; 14(1):445. DOI: 10.1038/s41598-023-50870-2

  2. Oestereicher MA, Wotton JM, Ayabe S, et al. Comprehensive ECG reference intervals in C57BL/6N substrains provide a generalizable guide for cardiac electrophysiology studies in mice. Mamm Genome. 2023; 34(2):180-199. DOI: 10.1007%2Fs00335-023-09995-y

  3. Kahnau P, Mieske P, Wilzopolski J, et al. A systematic review of the development and application of home cage monitoring in laboratory mice and rats. Bmc Biol. 2023; 21(1):256. DOI: 10.1186/s12915-023-01751-7

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