INFRAFRONTIER is the European Research Infrastructure for Modelling Human Diseases

We contribute to human health by advancing disease prevention and therapies through appropriate models.

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Cryopreservation Protocols EMMA Cre-driver EUCOMM IMPC Rare Disease COVID-19 Cancer

About INFRAFRONTIER

The INFRAFRONTIER consortium consists of more than 20 leading biomedical research institutes in 15 countries working together to understand basic mammalian gene function and model human diseases.

EMMA

The European Mouse Mutant Archive – EMMA is a non-profit repository for the collection, archiving (via cryopreservation) and distribution of relevant mutant mouse and rat strains essential for basic biomedical research.

Resources and Services

In addition to EMMA, INFRAFRONTIER offers other services like axenic derivation, access to open calls and systemic phenotyping.

Animal Welfare and Ethics

Discover INFRAFRONTIER’s commitment to Animal Welfare and explore the ethical research practices we apply to drive the 3R Principle in animal research.

In the Spotlight

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INFRAPLUS

A Horizon-INFRA-DEV project that aims to expand INFRAFRONTIER’s capacity for human disease modelling, refine its service portfolio by reducing animal usage and developing alternative cellular models, and optimise the use of resources.

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INFRAFRONTIER Cancer Services

Via the canSERV project, INFRAFRONTIER offers access to several cutting-edge cancer services as Open Calls. These services are offered by INFRAFRONTIER partners with world-leading expertise in cancer research and mouse models.

Axenic Service

This service offers the germ-free derivation of user-provided mouse strains for gnotobiotic studies.

Rodent Model Generation

Generation of custom rodent mutant strains using the latest genome-editing technologies by expert laboratories.

COVID-19 Resources and Services

INFRAFRONTIER offers a cutting-edge COVID-19 therapeutics pipeline, a large selection of COVID-19-related strains and emergency archiving services to aid COVID-19 research and minimise the loss of valuable mouse strains.

INFRAFRONTIER and Cancer Research

Browse through EMMA strains associated to more than 50 different cancer types and a list of manually-curated disease models for cancer.

IMPC

INFRAFRONTIER is closely linked to the largest and foremost scientific consortium for mouse phenotyping worldwide – the International Mouse Phenotyping Consortium (IMPC).

Strain Distribution

Prices, Delivery Times, Legal Questions and everything you need to know before ordering mutant strains from us.

Strain Collections

Strains originated by large-scale projects archived and distributed by EMMA.

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Press Kit

INFRAFRONTIER Consortium

Upcoming Trainings & Events

Virtual Pub “Special Edition”

22 November 2024

Euro-BioImaging

on-line

Michael Raess (and more)

FELASA 2025

02 - 05 June 2025

FELASA

Athens, Greece

Asrar Ali Khan, Auke Börsma, Tania Sorg & Maik Dahlhoff

FEBS 2025 – 49th FEBS Congress

05 - 09 July 2025

FEBS

Istanbul, Turkey

INFRAFRONTIER, INSTRUCT, EU-OPENSCREEN & Euro-BioImaging

Latest News

Event October 2, 2024

The INFRAPLUS Project Successfully Launched in Munich

The INFRAPLUS’s kick-off took place over two productive days in Munich. With lively discussions and concrete plans, we have set the stage for INFRAFRONTIER’s expansion in state-of-the-art in vivo models, innovative in vitro models, preclinical services, and data analysis. All set to get started!

Scientific Publication July 24, 2024

OBSERVE: guidelines for the refinement of rodent cancer models

Our partners at NKI and colleagues have developed the OBSERVE guidelines to improve the preparation and reporting of in vivo cancer studies in rodents. The guidelines provide detailed instructions on optimal preparation, implantation methods, and monitoring criteria. They also address expected adverse effects and offer tools to minimise distress and pain in animal models, promoting ethical practices and animal welfare in cancer research.

Event July 15, 2024

Two Networking and Outreach Events Define the Start of Summer

July has brought two major networking opportunities to INFRAFRONTIER: the 48th FEBS Congress in Milan, where we joined EURO-BioImaging, EU-OPENSCREEN, and Instruct, and the RExPO 4EU event in Munich focused on Drug Repurposing. Both events were enriching experiences that promise to foster new collaborations and enhance our outreach.

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